The mutational spectrum revealed by paired genome sequences from a lung cancer patient
Nature Volume 465 | 27 May 2010
Lung cancer is the leading cause of cancer-related mortality worldwide. Non-small-cell lung carcinomas in smokers are the predominant form of the disease. Although previous studies have identified common somatic mutations in lung cancers, they primarily focused on a small set of genes and provided a limited view of these cancers.
In this valuable article from Nature, you will discover how a recent cancer sequencing effort using Complete Genomics sequencing service provided a complete genome analysis of a primary lung tumor and adjacent normal tissue. This systematic comparison gives a global view of the complex mutation landscape of a non-small-cell lung carcinoma.
The study describes:
- Complete genome sequencing of the tumor and adjacent normal tissue samples from a 51-year-old male smoker who developed adenocarcinoma
- Somatic variations detected including SNPs, indels, and structural variations
- Distribution of somatic mutations in the genome
- Validation of somatic alterations
- Impact of multiple mutations on pathways
Complete Genomics next generation technology is also being applied to identify genome-wide mutations in leukemia, breast cancer and other cancer cell lines. Such a broad view provides new opportunities for cancer classification and biomarker selection.
Complete Genomics provides high quality, low-cost complete human genome sequencing and analysis services that enable researchers to carry out large-scale disease studies.
Complete Genomics, Inc., 2071 Stierlin Ct., Mountain View, CA 94043 USA